按照原廠的說法好像是可以用在全片幅DSLR
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Mr. Morio Ono, President of Tamron Co., Ltd., has announced the successful development of the AF28-300mm F/3.5-6.3 XR Di VC LD Aspherical (IF) MACRO zoom lens, a high power zoom lens designed for SLR cameras with full-size format(Model A20), now equipped with a Vibration Compensation (VC) mechanism. The AF28-300mm F/3.5-6.3 XR Di VC is the ultimate high power zoom lens that covers everything from wide-angle to telephoto and macro. Tamron has incorporated a Vibration Compensator, an anti-shake mechanism developed by Tamron, into the highly versatile zoom lens. The new AF28-300mm F/3.5-6.3 XR Di VC LD Aspherical (IF) MACRO zoom lens offers the convenience, comfort and versatility of a high power zoom lens and the capability to reduce hand-shake blur on SLR cameras using either APS-C size or full size format imagers.
When the AF28-300mm F/3.5-6.3 XR Di VC is used with a full size format SLR camera, it covers the tremendous focal length range from 28mm in wide angle to 300mm ultra telephoto. When mounted on a DSLR with an APS-C sized imager, the lens covers a 43mm wide angle to 465mm equivalent ultra telephoto* (full size format equivalent, in a diagonal angle of view of 5°20').

(*) The ratio Tamron uses to convert from full size format to APS-C focal length is 1.55X.
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全文見 http://www.tamron.co.jp/en/news/release_2007/0307_a20.html